Depression is one of the leading causes of various health problems in modern society. According to a recent report (1), depression will become the second most common health problem in the world because of the emerging lifestyle. The emerging technologies are changing the normal lifestyle and people are working extra hard to meet the new needs. Increasing cases of single-parenting, divorce, tough economic conditions, joblessness, and family pressure are likely going to increase levels of depression, especially among those aged 30 years or older. According to a recent study (2), the problem that medical practitioners face when dealing with depression is that most patients often ignore it. People rarely consider extreme stress as a medical condition that may require medical attention. If it is left unchecked, depression can lead to other serious health problems, besides disruptive the social and economic status of an individual. Studies have indicated that hypertension is often caused by depression (3). The studies show that both depression and hypertension share a common pathway, so it is possible for depression to lead to hypertension. Hypertension is also becoming common among adults. In Saudi Arabia alone, studies suggest that the prevalence of hypertension is 27% among those who are aged 30 years and above. In this paper, the focus is to determine the effect of hypertension on primary health care depressive patients.